- Toxicity summary： 美沙比妥结合于与GABA<sub>A</sub>受体上Cl<sup>-</sup>离子通道相关的独特结合位点，增加了Cl<sup>-</sup>离子通道开放的时间。因此，GABA在丘脑的突触后抑制作用延长。所有这些效应都与GABA敏感神经元钙电导(gCa)的显著降低相关。巴比妥类药物作用的净结果是急性增强抑制性GABA能张力。巴比妥类药物还通过强效(尽管特征不那么明确)和直接抑制兴奋性AMPA型谷氨酸受体发挥作用，导致谷氨酸能神经传递的显著抑制。
- Health Effects： 可能引起潜在危险的皮疹，可能发展为史蒂文斯-约翰逊综合征，这是一种极其罕见但可能致命的皮肤疾病。
- ecotoxicity value： USDA APHIS化学品影响：collection=usda_chemeffect&query_type=synonym&query='^50-11-3$'
- Symptoms and Signs： 过量的迹象包括意识混乱（严重）、反射减弱或丧失、嗜睡（严重）、发烧、易怒（持续）、体温过低、判断力差、呼吸困难或呼吸缓慢或困难、心跳缓慢、言语不清、蹒跚、睡眠困难、眼球异常运动、虚弱（严重）。
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
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metharbital 5mg
metharbital 5mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 5mg.
