MPBH(4-(4-N-maleimidophenyl)butyric acid hydrazide)

MPBH(4-(4-N-马来酰亚胺苯基)丁酸酰肼)

MPBH(4-(4-N-maleimidophenyl)butyric acid hydrazide)

M638944-50mg

50mg

2-8°C储存,干燥

冰袋运输

Product introduction： MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates). Features of MPBH: • Reactive groups: maleimide andhydrazide • Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups • Long (17.9A), sulfhydryl-to-aldehyde crosslinker with an aromatic ring in its spacer arm (noncleavable) • Maleimide group reacts with sulfhydryl groups to form stable thioether linkages • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups Product References: Crosslinker Application Guide -- search for recent literature references for this product • Reactive Moiety: Amine,Hydrazide,Maleimide • Crosslinker Type: Heterobifunctional • Form: Powder • Spacer: Medium(10 to 30 Å) • Labeling Method: Chemical Labeling • Spacer Arm Length: 17.9 Å

309.75 g/mol

DMF,DMSO

Carbohydrate-Sulfhydryl