MOMIPP

小分子

甲基异丙基苯

MOMIPP

M646552-5mg

5mg

≥99%

-20°C储存

超低温冰袋运输

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB). In Vitro MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations. In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization. MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: U251 cells Concentration: 10 μM Incubation Time: 4 h or 24 h Result: Activated the JNK stress kinase pathway. In Vivo MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)Dosage: 80 mg/kg Administration: i.p.; once daily; for 15 consecutive days Result: Suppressed progression of intracerebral glioblastoma xenografts. Form:Solid

MOMIPP是一种巨细胞吞噬诱导剂，是一种PIKfyve抑制剂。MOMIPP 可穿透血脑屏障（BBB）。

1363421-46-8

C18H16N2O2

292.3 g/mol

51039247

CC1=C(C2=C(N1)C=CC(=C2)OC)/C=C/C(=O)C3=CC=NC=C3

(E)-3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-pyridin-4-ylprop-2-en-1-one

1S/C18H16N2O2/c1-12-15(4-6-18(21)13-7-9-19-10-8-13)16-11-14(22-2)3-5-17(16)20-12/h3-11,20H,1-2H3/b6-4+

UPJCYXIOWHZRLU-GQCTYLIASA-N

CC1=C(C2=C(N1)C=CC(=C2)OC)C=CC(=O)C3=CC=NC=C3

51039247

3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one;MOMIPP

DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C)

1

3

4

292.121 Da

292.121 Da

55.000 Ų

22

0

417.000

0

1

3.100