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Product introduction

MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC 50 of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs). In Vitro MLS-0437605 efficiently inhibits platelet aggregation in response to collagen related peptide (CRP) and rhodocytin, but not after stimulation with thromboxane. MLS-0437605 causes a decrease in pY of a ~70-kDa band after stimulation with CRP or rhodocytin. Tyrosine phosphorylation of immunoprecipitated Syk and PLCγ2 is also reduced by MLS-0437605. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

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Chinese name

MLS-0437605

English name

MLS-0437605

Chinese alias

English alias

CAS number

862975-18-6

molecular formula

C16H11FN4O2S

molecular weight

342.35 g/mol

Exact mass

≥99%

PSA

Logp

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