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Product details

名称

ML148

分子类型

小分子

英文名称

ML148

货号

M647091-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ML148 is a potent and selective 15-PGDH inhibitor with an IC 50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways In Vitro ML148 (compound 13) shows selectivity with IC 50 s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively. ML148 (10, 20 nM) decrease V max by 25% and reduces the apparent K m by half at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC 50 : 56 nM (15-PGDH)

生化机理

ML148 是一种强效的选择性 15-PGDH 抑制剂，其 IC 50 为 56 nM。ML148 具有研究前列腺素信号通路的潜力。

CAS号

451496-96-1

分子式

C20H21N3O

分子量

319.4 g/mol

PubChem编号

3243760

Isomeric SMILES

CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

IIUPAC Name

[1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone

INCHI

1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3

InChi Key

YQNOQZALLOQMPY-UHFFFAOYSA-N

Smiles

CC1=CC(=CC=C1)N2C=NC3=C2C=CC(=C3)C(=O)N4CCCCC4

PubChem CID

3243760

溶解性

DMSO : 50 mg/mL (156.54 mM; ultrasonic and warming and heat to 80°C)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

319.168 Da

单同位素质量Monoisotopic Mass

319.168 Da

拓扑极表面积Topological Polar Surface Area

38.100 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

448.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.800

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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