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Product details

名称

MKC9989

分子类型

小分子

英文名称

MKC9989

货号

M647927-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

MKC9989 is a Hydroxy aryl aldehydes ( HAA ) inhibitor and also inhibits IRE1α with an IC 50 of 0.23 to 44 μM. In Vitro At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC 50 =0.33 μM) is comparable to its potency against RNA cleavage in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.23 to 44 μM (IRE1α)

生化机理

MKC9989 是一种羟基芳基醛（HAA）抑制剂，也能抑制 IRE1α，其 IC 50 为 0.23 至 44 μM。

CAS号

1338934-20-5

分子式

C17H20O7

分子量

336.34 g/mol

PubChem编号

89542001

Isomeric SMILES

CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CCOCCOC

IIUPAC Name

7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxochromene-8-carbaldehyde

INCHI

1S/C17H20O7/c1-10-11(4-5-23-7-6-21-2)17(20)24-16-12(10)8-14(22-3)15(19)13(16)9-18/h8-9,19H,4-7H2,1-3H3

InChi Key

QSVDQIXSUDHAOF-UHFFFAOYSA-N

Smiles

CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CCOCCOC

PubChem CID

89542001

MeSH Entry Terms

MKC9989

溶解性

DMSO : ≥ 50 mg/mL (148.66 mM)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

336.121 Da

单同位素质量Monoisotopic Mass

336.121 Da

拓扑极表面积Topological Polar Surface Area

91.300 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

487

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

1.4

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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