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名称

Mardepodect hydrochloride

别名

盐酸马德普特

英文别名

英文名称

Mardepodect hydrochloride

货号

M649719-5mg

包装规格

5mg

浓度

≥95%

储存温度

2-8°C储存,干燥

运输条件

冰袋运输

产品介绍

Mardepodect hydrochloride (PF-2545920 hydrochloride) is a potent, orally active and selective PDE10A inhibitor with an IC 50 of 0.37 nM, with >1000-fold selectivity over other PDEs . Mardepodect hydrochloride can cross the blood-brain barrier In Vivo In the conditioned avoidance response assay (CAR), Mardepodect (PF-2545920) is active with an ED 50 of 1 mg/kg. Administration of Mardepodect (PF-2545920) to mice causes a dose dependent increase in striatal cGMP. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 0.37 nM (PDE10A)

生化机理

Mardepodect hydrochloride（PF-2545920 盐酸盐）是一种强效、具有口服活性和选择性的 PDE10A 抑制剂，其 IC 50 为 0.37 nM，与其他 PDE 相比，选择性大于 1000 倍。Mardepodect 盐酸盐可透过血脑屏障。

CAS号

2070014-78-5

分子式

C25H21ClN4O

分子量

428.91 g/mol

PubChem编号

122412737

Isomeric SMILES

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

IIUPAC Name

2-[[4-(1-methyl-4-pyridin-4-ylpyrazol-3-yl)phenoxy]methyl]quinoline;hydrochloride

INCHI

1S/C25H20N4O.ClH/c1-29-16-23(18-12-14-26-15-13-18)25(28-29)20-7-10-22(11-8-20)30-17-21-9-6-19-4-2-3-5-24(19)27-21;/h2-16H,17H2,1H3;1H

InChi Key

BDHTXAXWOXYUDG-UHFFFAOYSA-N

Smiles

CN1C=C(C(=N1)C2=CC=C(C=C2)OCC3=NC4=CC=CC=C4C=C3)C5=CC=NC=C5.Cl

PubChem CID

122412737

关联CAS

2070014-78-5

溶解性

DMSO : 25 mg/mL (58.29 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

428.14 Da

单同位素质量Monoisotopic Mass

428.14 Da

拓扑极表面积Topological Polar Surface Area

52.800 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

531

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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