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Product introduction

MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates ( ADC s) such as Vorsetuzumab mafodotin and SGN-CD19A In Vitro MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC 50 s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Auristatin

Specs ⸢ View details ⸥

Chinese name

MMAF sodium

English name

MMAF sodium

Chinese alias

English alias

CAS number

1799706-65-2

molecular formula

C39H64N5NaO8

molecular weight

753.94 g/mol

Exact mass

≥99%

PSA

Logp

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