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Product details

名称

MRK-740

分子类型

未知

英文名称

MRK-740

货号

M650325-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC 50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9 -dependent trimethylation of H3K4 ( IC 50 = 0.8 µM) In Vitro After 24?h of treatment, MRK-740 (3?μM) does not affect HEK293T cell growth at the IC 90 , but some toxicity is observed at 10?μM. MRK-740 is an equipotent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 80 nM (PRDM9)

生化机理

MRK-740 是一种强效、选择性和底物竞争性 PRDM9 组蛋白甲基转移酶抑制剂，IC 50 为 80u2009nM。与其他组蛋白甲基转移酶和其他非表观遗传靶标相比，MRK-740 对 PRDM9 的选择性更高。MRK-740 可降低 PRDM

CAS号

2387510-80-5

分子式

C25H32N6O3

分子量

464.56 g/mol

PubChem编号

137331596

Isomeric SMILES

CC1=NC=CC(=C1)N2CCC3(CC2)CN(CCN3C)C4=NC(=NO4)C5=CC(=CC(=C5)OC)OC

IIUPAC Name

3-(3,5-dimethoxyphenyl)-5-[1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-4-yl]-1,2,4-oxadiazole

INCHI

1S/C25H32N6O3/c1-18-13-20(5-8-26-18)30-9-6-25(7-10-30)17-31(12-11-29(25)2)24-27-23(28-34-24)19-14-21(32-3)16-22(15-19)33-4/h5,8,13-16H,6-7,9-12,17H2,1-4H3

InChi Key

NZYTZRHHBAJPKN-UHFFFAOYSA-N

Smiles

CC1=NC=CC(=C1)N2CCC3(CC2)CN(CCN3C)C4=NC(=NO4)C5=CC(=CC(=C5)OC)OC

PubChem CID

137331596

溶解性

DMSO : 40 mg/mL (86.10 mM; Need ultrasonic and warming)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

464.254 Da

单同位素质量Monoisotopic Mass

464.254 Da

拓扑极表面积Topological Polar Surface Area

80.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

651

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.5

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

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