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Product details

名称

(S)-Mapracorat

别名

(S)-马普拉科拉

英文名称

(S)-Mapracorat

货号

M650642-5mg

包装规格

5mg

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist. In Vitro (S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC 50 value of approximately 0.2 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

(S)-Mapracorat 是一种选择性和活性较低的糖皮质激素受体激动剂。

CAS号

887375-15-7

分子式

C25H26F4N2O2

分子量

462.48 g/mol

PubChem编号

24993922

Isomeric SMILES

CC1=NC2=C(C=C1)C(=CC=C2)NC[C@@](CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O

IIUPAC Name

(2S)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol

INCHI

1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m0/s1

InChi Key

VJGFOYBQOIPQFY-DEOSSOPVSA-N

Smiles

CC1=NC2=C(C=C1)C(=CC=C2)NCC(CC(C)(C)C3=CC(=CC4=C3OCC4)F)(C(F)(F)F)O

PubChem CID

24993922

溶解性

DMSO : ≥ 50.6 mg/mL (109.41 mM)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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