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Product introduction

MC-GGFG-AM-(10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3 . ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells IC50& Target:Topoisomerase I

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Chinese name

MC-GGFG-AM-(10Me-11F-Camptothecin)

English name

MC-GGFG-AM-(10Me-11F-Camptothecin)

Chinese alias

MC-GGFG-AM-(10Me-11F-喜树碱)

English alias

CAS number

2873460-70-7

molecular formula

C51H56FN9O14

molecular weight

1038.04 g/mol

Exact mass

PSA

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