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Product details

名称

MK2-IN-1 hydrochloride

分子类型

小分子

别名

MK2-IN-1盐酸盐

英文名称

MK2-IN-1 hydrochloride

货号

M651058-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存

运输条件

冰袋运输

产品介绍

MK2-IN-1 hydrochloride is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.IC50 value: 0.11 uM Target: MAPKAPK2(MK2) inhibitorMK2-IN-1 was profiled for kinase selectivity by screening against a broad panel of 150 protein kinases at a concentration of 10 μM, and only CK1γ3 was significantly inhibited at greater than 50%. MK2-IN-1 inhibited pro-inflammatory cytokine secretion from the human THP1 acute monocytic leukemia cell line, causing dose-dependent inhibition of LPS-stimulated TNFα and IL6 secretion. MK2-IN-1 also dose dependently inhibited IL1β-stimulated matrixmetalloprotease (MMP)13 secretion from the SW1353 chondrosarcoma cell line and human primary chondrocyte cultures. Of note, given its high degree of selectivity, our data suggest that MK2-IN-1 may be an excellent pharmacologic tool for specifically exploring and validating MK2 biology . Form:Solid

生化机理

MK2-IN-1 hydrochloride 是一种强效的 MAPKAPK2(MK2) 选择性抑制剂（IC50=0.11 uM），具有非 ATP 竞争性结合模式：MAPKAPK2(MK2) 抑制剂（nMK2-IN-1 是通过筛选对

CAS号

1314118-94-9

分子式

C27H26Cl2N4O2

分子量

509.4 g/mol

PubChem编号

70681199

Isomeric SMILES

C1CN(CCN1)C2=CC=C(C=C2)N(CC3=CC=CC=N3)C(=O)C4=CC=C(O4)C5=CC=C(C=C5)Cl.Cl

IIUPAC Name

5-(4-chlorophenyl)-N-(4-piperazin-1-ylphenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide;hydrochloride

INCHI

1S/C27H25ClN4O2.ClH/c28-21-6-4-20(5-7-21)25-12-13-26(34-25)27(33)32(19-22-3-1-2-14-30-22)24-10-8-23(9-11-24)31-17-15-29-16-18-31;/h1-14,29H,15-19H2;1H

InChi Key

AZDOSXSDARWKGX-UHFFFAOYSA-N

Smiles

C1CN(CCN1)C2=CC=C(C=C2)N(CC3=CC=CC=N3)C(=O)C4=CC=C(O4)C5=CC=C(C=C5)Cl.Cl

PubChem CID

70681199

溶解性

H2O : ≥ 100 mg/mL (196.30 mM) DMSO : 100 mg/mL (196.30 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

508.143 Da

单同位素质量Monoisotopic Mass

508.143 Da

拓扑极表面积Topological Polar Surface Area

61.600 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

645.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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