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Product details

名称

Merafloxacin

分子类型

小分子

别名

美拉沙星

英文别名

CI-934 | NCGC00263138-01 | J-517971 | 1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | 1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic aci

英文名称

Merafloxacin

货号

M651146-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses . Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria In Vitro Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC 50 s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 19.6 μM (SARS-CoV-2)

生化机理

美拉沙星（CI-934）是一种氟喹诺酮类抗菌剂，是一种选择性的β冠状病毒-1核糖体框架转换（-1 PRF）抑制剂。美拉沙星对革兰氏阳性菌和革兰氏阴性菌具有体外活性。

CAS号

91188-00-0

分子式

C19H23F2N3O3

分子量

379.40 g/mol

PubChem编号

121833

Isomeric SMILES

CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F

IIUPAC Name

1-ethyl-7-[3-(ethylaminomethyl)pyrrolidin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

INCHI

1S/C19H23F2N3O3/c1-3-22-8-11-5-6-24(9-11)17-14(20)7-12-16(15(17)21)23(4-2)10-13(18(12)25)19(26)27/h7,10-11,22H,3-6,8-9H2,1-2H3,(H,26,27)

InChi Key

BAYYCLWCHFVRLV-UHFFFAOYSA-N

Smiles

CCNCC1CCN(C1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CC)F

PubChem CID

121833

关联CAS

110013-21-3,91188-00-0

MeSH Entry Terms

1-ethyl-7-(3-((ethylamino)methyl)-1-pyrrolidinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;CI 934;CI-934

溶解性

DMSO : 11.11 mg/mL (29.28 mM; ultrasonic and adjust pH to 3 with HCl)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

379.171 Da

单同位素质量Monoisotopic Mass

379.171 Da

拓扑极表面积Topological Polar Surface Area

72.900 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

615

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

-0.1

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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