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名称

MS645

英文名称

MS645

货号

M651941-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

MS645 is a bivalent BET bromodomains (BrD) inhibitor with a K i of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cells In Vitro MS645 has cell growth inhibitory effects on noncancer cell lines of mouse macrophage RAW cells and nontumorigenic breast epithelial MCF10A with IC 50 s of 4.1 nM, 6.8 nM, 7.9 nM for triple-negative breast cancer (TNBC) cell lines HS5878T, BT549, and MCF 10A. ?\nMS645 (15, 30, 60 nM) results in a dramatic reduction of c-Myc expression and an increase of p21, a tumor suppressor and cell-cycle inhibitor in HCC1806 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:BRD4(BD1BD2) 18.4 nM (Ki)

生化机理

MS645 是一种双价 BET 溴odomains (BrD) 抑制剂，对 BRD4-BD1/BD2 的 K i 为 18.4 nM。MS645 在空间上限制了对 BRD4 BrDs 的二价抑制，从而持续抑制了实体瘤细胞中 BRD4 的转录活性。

CAS号

2250091-96-2

分子式

C48H54Cl2N10O2S2

分子量

938.04 g/mol

PubChem编号

137349088

IIUPAC Name

2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[10-[[2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetyl]amino]decyl]acetamide

INCHI

1S/C48H54Cl2N10O2S2/c1-27-29(3)63-47-41(27)43(33-15-19-35(49)20-16-33)53-37(45-57-55-31(5)59(45)47)25-39(61)51-23-13-11-9-7-8-10-12-14-24-52-40(62)26-38-46-58-56-32(6)60(46)48-42(28(2)30(4)64-48)44(54-38)34-17-21-36(50)22-18-34/h15-22,37-38H,7-14,23-26H2,1-6H3,(H,51,61)(H,52,62)/t37-,38-/m0/s1

InChi Key

VFGPQYYCEGAFLY-UWXQCODUSA-N

Smiles

CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCCCCCCCCCNC(=O)CC4C5=NN=C(N5C6=C(C(=C(S6)C)C)C(=N4)C7=CC=C(C=C7)Cl)C)C8=CC=C(C=C8)Cl)C

PubChem CID

137349088

溶解性

DMSO : 200 mg/mL (213.21 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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