Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC 50 of 50 nM. In Vitro Mps1-IN-3 is a potent MPS1 kinase inhibitor, with an IC 50 of 50 nM. Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells with an IC 50 of appr 5 µM. Mps1-IN-3 (2 μM) can completely abrogates checkpoint. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Mps1-IN-3 (2 mg/kg, i.v.) sensitizes glioblastoma cells in murine tumor models, with prolonged survival and no toxicity . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Mps1 50 nM (IC 50 )