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名称

MI-773

分子类型

小分子

英文名称

MI-773

货号

M654852-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

充氩,-80℃储存

运输条件

超低温冰袋运输

产品介绍

MI-773 is a potent MDM2-p53 protein‐protein interaction (PPI) inhibitor with high binding affinity against MDM2 (K d =8.2 nM). MI-773 has antitumor activity. In Vitro SAR405838 (MI-77301), an analog of MI-773, displays 10 times higher binding affinity against MDM2 than MI-773 (K d =62 vs 8.2 nM). The antitumor activity of MI-77301 is more pronounced in a set of wild type p53 xenograft models than MI-773, including SJSA-1 osteosarcoma, human prostate, melanoma, colorectal tumor, LNCAP human prostate tumor and human acute lymphoblastic leukemia. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生化机理

MI-773 是一种强效的 MDM2-p53 蛋白-蛋白相互作用（PPI）抑制剂，与 MDM2 的结合亲和力很高（K d =8.2 nM）。MI-773 具有抗肿瘤活性。

CAS号

1303607-07-9(DMSO)

分子式

C29H34Cl2FN3O3

分子量

562.5 g/mol

Smiles

CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

Reaxy-Rn

32303642

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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