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Product details

名称

MKC9989

英文名称

MKC9989

货号

M655228-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

MKC9989 is a Hydroxy aryl aldehydes ( HAA ) inhibitor and also inhibits IRE1α with an IC 50 of 0.23 to 44 μM. In Vitro At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC 50 =0.33 μM) is comparable to its potency against RNA cleavage in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 0.23 to 44 μM (IRE1α)

生化机理

MKC9989 是一种羟基芳基醛（HAA）抑制剂，也能抑制 IRE1α，其 IC 50 为 0.23 至 44 μM。

CAS号

1338934-20-5(DMSO)

分子式

C17H20O7

分子量

336.34 g/mol

Smiles

CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CCOCCOC

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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