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Product introduction

MZP-55 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4 , with a K d of 8 nM for Brd4 BD2 . In Vitro MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a K d of 8 nM for Brd4 BD2 . MZP-55 binds to VHL-EloC-EloB protein (VCB) with a K d of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC 50 s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Kd: 8 nM (Brd4 BD2 )

Specs ⸢ View details ⸥

Chinese name

MZP-55

English name

MZP-55

Chinese alias

English alias

HY-112377 | SCHEMBL18076334 | BDBM50459881 | MZP-55 | 2010159-48-3 | AKOS037653403 | (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[[4-[(2S,4R)-1-acetyl-4-(4-chloroanilino)-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-

CAS number

2010159-48-3

molecular formula

C57H70ClN7O10S

molecular weight

1080.72 g/mol

Exact mass

≥99%

PSA

238.000 Å²

Logp

6.400

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