Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

Mizacorat

别名

米萨科拉特

英文名称

Mizacorat

货号

M656113-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation In Vivo Mizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model. IC50& Target:IC50: 3.8 nM (Glucocorticoid receptor)

生化机理

Mizacorat（AZD9567；化合物 15）是一种强效的口服活性非甾体选择性糖皮质激素受体调节剂（SGRM），IC 50 为 3.8 nM。在链球菌细胞壁（SCW）再活化关节炎模型中表现出卓越的疗效

CAS号

1893415-00-3(DMSO)

分子式

C27H28F2N4O3

分子量

494.53 g/mol

Smiles

CC(C)C(C(C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！