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Product details

名称

MRK-740

英文名称

MRK-740

货号

M656223-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

MRK-740 is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC 50 of 80 nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9 -dependent trimethylation of H3K4 ( IC 50 = 0.8 µM) In Vitro After 24?h of treatment, MRK-740 (3?μM) does not affect HEK293T cell growth at the IC 90 , but some toxicity is observed at 10?μM. MRK-740 is an equipotent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 specifically and directly inhibits H3K4 methylation at endogenous PRDM9 target loci. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 80 nM (PRDM9)

生化机理

MRK-740 是一种强效、选择性和底物竞争性 PRDM9 组蛋白甲基转移酶抑制剂，IC 50 为 80u2009nM。与其他组蛋白甲基转移酶和其他非表观遗传靶标相比，MRK-740 对 PRDM9 的选择性更高。MRK-740 可降低 PRDM

CAS号

2387510-80-5(DMSO)

分子式

C25H32N6O3

分子量

464.56 g/mol

Smiles

CC1=NC=CC(=C1)N2CCC3(CC2)CN(CCN3C)C4=NC(=NO4)C5=CC(=CC(=C5)OC)OC

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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