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名称

Mutant IDH1-IN-2

别名

突变型IDH1-IN-2

英文名称

Mutant IDH1-IN-2

货号

M656677-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1 Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer . More bioactivity information in Patent WO 2013046136A1 (Example 224).

生化机理

Mutant IDH1-IN-2 是突变型异柠檬酸脱氢酶（IDH）蛋白的抑制剂，在 LS-MS 生化检测中的 IC50 为 16.6 nM，在荧光生化检测中的 IC50 为 16.6 nM：突变体 IDH1 突变体 IDH1-IN-2 具有新变态活性，在治疗突变体 IDH1 和 IDH1-IN-2 的过程中，其活性与突变体 IDH1 和 IDH1-IN-2 的活性相同。

CAS号

1429176-69-1(DMSO)

分子式

C24H31F2N5O2

分子量

459.53 g/mol

Smiles

O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=CC=C(CN4CCC(F)(F)CC4)C=C3)C)=NC=C2

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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