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Product details

名称

MRTX9768 hydrochloride

别名

MRTX9768 盐酸盐

英文名称

MRTX9768 hydrochloride

货号

M659405-5mg

包装规格

5mg

浓度

≥99%

储存温度

避光,-20°C储存,干燥

运输条件

超低温冰袋运输

产品介绍

MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. Appearance:Solid IC50& Target:PRMT5•MTA In Vitro:MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC 50 3 nM; prolif. IC 50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC 50 544 nM; prolif. IC 50 861 nM). MRTX9768 (0-250 nM) results in LU99 SDMA inhibi In Vivo:In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow. MRTX9768 selectively targets MTAP/CDKN2A-deleted tumors (such as glioblastoma) Biological Activity:MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.

分子式

C24H18ClFN6O

分子量

460.89 g/mol

Smiles

N#CC1=C(C2=C(C3=CC4=C(C(NN=C4CN)=O)C=C3)C=NN2C)C(F)=CC5=C1C=CC=C5.[H]Cl

溶解性

H2O : 40 mg/mL (86.79 mM; Need ultrasonic) DMSO : 19 mg/mL (41.22 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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