MY33-3 hydrochloride is a potent and selective inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ , with an IC 50 of ~0.1 μM. MY33-3 hydrochloride also inhibits PTP-1B ( IC 50 ~0.7 μM). MY33-3 hydrochloride can reduce ethanol consumption and alleviate Sevoflurane-induced neuroinflammation and cognitive dysfunction . In Vitro MY33-3 hydrochloride (1 μM; pretreated for 5 min) blocks Ethanol-induced activation of TrkA and ALK in SH-SY5Y cells. MY33-3 hydrochloride (0.1-10 μM; 24 h) limits LPS-induced nitrites production and iNos increases in BV2 microglial cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo MY33-3 hydrochloride (60 mg/kg; p.o. on days 3 and 4) reduces ethanol consumption when comparing day 2 with day 3. MY33-3 hydrochloride reduces preference for the ethanol solution on day 3 . MY33-3 hydrochloride (i.p.) reverses the Sevoflurane-induced decrease in the discrimination index and impaired motor learning ability. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid