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Product introduction

HDAC3-IN-T247是一种有效的选择性 HDAC3 (组蛋白去乙酰化酶 3) 抑制剂。HDAC3-IN-T247 诱导 HCT116 细胞选择性增加 NF-κB 乙酰化。HDAC3-IN-T247 具有抗癌和抗病毒活性。HDAC3-IN-T247 能抑制癌细胞生长，激活潜伏在 HIV 感染细胞中的 HIV 基因表达。 HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells.

Specs ⸢ View details ⸥

Chinese name

HDAC3-抑制剂-T247

English name

HDAC3-IN-T247

Chinese alias

N-(2-氨基苯基)-4-[1-[2-(3-噻吩基)乙基]-1H-1,2,3-三唑-4-基]苯甲酰胺

English alias

CAS number

1451042-18-4

molecular formula

C21H19N5OS

molecular weight

389.48 g/mol

Exact mass

≥95%

PSA

114.000 Å²

Logp

3.100

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