N-去甲基西地那非-d8是氘代西地那非的类似物。西地那非是5型cGMP磷酸二酯酶的选择性抑制剂（PDE5抑制剂），可催化3'，5'-环鸟苷单磷酸（cGMP）的水解。作为PDE5抑制剂，据报道西地那非可增强中风大鼠模型的神经，突触和血管生成，并且据报道是温和的血管扩张剂。西地那非还显示可通过依赖NO / cGMP的机制防止吲哚美辛诱导的小肠溃疡形成。 N-Desmethyl Sildenafil-d8 is a deuterium-labelled analog of Sildenafil . Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin-induced small intestinal ulceration formation through an NO/cGMP- dependent mechanism.