脂质A是内毒素的富含脂质的成分，也称为脂多糖（LPS），而脂多糖又是革兰氏阴性细菌外膜的一部分。脂质A激活Toll样受体4（TLR4），从而引发免疫反应。TLR4的脂质A激活的拮抗剂，在使用修饰的人胚肾（HEK）细胞的基于细胞的测定中显示出1.68μM的IC50值。它不会显着影响HEK细胞的生存能力。在脓毒症模型中，使用腹膜内LPS时，这种化学物质可显着并显着改善小鼠的存活率 Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. An antagonist of Lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells. It does not significantly affect HEK cell viability. In a model of sepsis, this chemical dramatically and significantly improves survival of mice given intraperitoneal LPS