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Product introduction

N-(Azido-PEG2)-N-Boc-PEG4-acid 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。N-(Azido-PEG2)-N-Boc-PEG4-acid 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。 N-(Azido-PEG2)-N-Boc-PEG4-acid is a branched PEG derivative with a terminal azido group, Boc protected amino group, and a terminal carboxylic acid. The azide group enables PEGylation via Click Chemistry. The protected amine can be deprotected by acidic conditions. The terminal carboxylic acid can be reacted with primary amino groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

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Chinese name

N-(叠氮基-PEG2)-N-Boc-PEG4-酸

English name

N-(Azido-PEG2)-N-Boc-PEG4-acid

Chinese alias

N-(叠氮-二聚乙二醇)-N-叔丁氧羰基-四聚乙二醇-羧酸

English alias

N-(Azido-PEG2)-N-Boc-PEG4-acid | MS-29685 | 2093153-82-1 | HY-140525 | AKOS040742200 | DTXSID701107377 | C70167 | BP-23505 | 1-(13-azido-2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-5-yl)-3,6,9,12-tetraoxapentadecan-15-oic acid | 5,8,11,14-Tetraoxa-2-az

CAS number

2093153-82-1

molecular formula

C22H42N4O10

molecular weight

522.59 g/mol

Exact mass

≥98%

PSA

137.000 Å²

Logp

0.600

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