Share to

Details

Safety

Technical Documents

Articles

reviews

Consult

returns

Product details

名称

NBI-98782

分子类型

小分子

英文名称

NBI-98782

货号

N646649-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM Target: VMAT2The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection. Form:Solid

生化机理

NBI-98782(alpha-dihydrotetrabenazine) 是一种囊泡单胺转运体（VMAT2）抑制剂，Ki 值为 0.97 nM：(+)-异构体在体外显示出对 VMAT2 的高亲和力（Ki = 0.97 +/- 0.48 nM）。

CAS号

85081-18-1

分子式

C19H29NO3

分子量

319.44 g/mol

PubChem编号

14580381

Isomeric SMILES

CC(C)C[C@@H]1CN2CCC3=CC(=C(C=C3[C@H]2C[C@H]1O)OC)OC

Smiles

CC(C)C[C@@H]1CN2CCC3=CC(=C(C=C3[C@H]2C[C@H]1O)OC)OC

PubChem CID

14580381

溶解性

DMSO : 33.33 mg/mL (104.34 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

319.215 Da

单同位素质量Monoisotopic Mass

319.215 Da

拓扑极表面积Topological Polar Surface Area

41.900 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

389.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.200

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

user reviews

Consultation

Warm reminder：

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.！

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ，We will handle it for you as soon as possible, thank you for your support and trust.！