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名称

NH-3

分子类型

小分子

英文名称

NH-3

货号

N648043-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment In Vivo NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 55 nM (THR)

生化机理

NH-3 是一种口服活性、可逆的甲状腺激素受体（THR）拮抗剂，其 IC 50 为 55 nM。NH-3 是选择性甲状腺激素受体 GC-1 的衍生物，可抑制甲状腺激素与其受体的结合，并抑制辅助因子的招募[1]。

CAS号

447415-26-1

分子式

C28H27NO6

分子量

473.52 g/mol

PubChem编号

10027822

Isomeric SMILES

CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O

Smiles

CC1=CC(=CC(=C1CC2=CC(=C(C(=C2)C(C)C)O)C#CC3=CC=C(C=C3)[N+](=O)[O-])C)OCC(=O)O

PubChem CID

10027822

溶解性

DMSO : 100 mg/mL (211.18 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

473.184 Da

单同位素质量Monoisotopic Mass

473.184 Da

拓扑极表面积Topological Polar Surface Area

113.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

774

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

6.8

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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