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名称

NCGC00029283

分子类型

小分子

英文名称

NCGC00029283

货号

N648485-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC 50 s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. In Vitro NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: U2-OS cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 24 h, 48 h, 72 h Result: Showed a reduction in U2-OS cell proliferation. Form:Solid

生化机理

NCGC00029283 是一种维尔纳综合征螺旋酶核酸酶（WRN）螺旋酶抑制剂，对 WRN、BLM 和 FANCJ 螺旋酶的 IC 50 s 分别为 2.3 μM、12.5 μM 和 3.4 μM。

CAS号

714240-31-0

分子式

C18H12FN3O3

分子量

337.30 g/mol

PubChem编号

651756

Isomeric SMILES

COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

IIUPAC Name

3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-1H-quinolin-2-one

INCHI

1S/C18H12FN3O3/c1-24-13-6-7-15-11(8-13)9-14(17(23)20-15)16-21-18(25-22-16)10-2-4-12(19)5-3-10/h2-9H,1H3,(H,20,23)

InChi Key

FJQADEHMIMENRE-UHFFFAOYSA-N

Smiles

COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

PubChem CID

651756

溶解性

DMSO : 6.94 mg/mL (20.58 mM; ultrasonic and warming and heat to 60°C)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

337.086 Da

单同位素质量Monoisotopic Mass

337.086 Da

拓扑极表面积Topological Polar Surface Area

77.300 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

536.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

3.000

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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