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Product introduction

β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2 , MMP-2 and MMP-9 In Vitro β-Neo-Endorphin (0-20 μM, 20 h) stimulates wound healing in human keratinocytes. β-Neo-Endorphin (promotes wound healing through activation of the Erk1/2 signaling pathway in human keratinocytes. β-Neo-Endorphin (0-20 μM, 12 h) stimulates keratinocyte migration through activation of metalloproteinase (MMP)-2 and -9. β-Neo-Endorphin (12 h) stimulates migration in the fibroblast. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 20 h Result: Significantly increased the wound closure. Had no observable effect on cell viability. Western Blot AnalysisCell Line: Human keratinocytes (HaCaT) Concentration: 0, 5, 10 and 20 μM Incubation Time: 12 h Result: Activated Erk1/2, phosphorylated P90RSK and Elk-1, showed significant upregulation of MMP-2 and -9 expression. Form:Solid IC50& Target:ERK1 ERK2 MMP-2 MMP-9

Specs ⸢ View details ⸥

Chinese name

β-Neo-Endorphin

English name

β-Neo-Endorphin

Chinese alias

β-新内啡肽

English alias

BDBM82082 | (2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexano

CAS number

77739-21-0

molecular formula

C54H77N13O12

molecular weight

1100.27 g/mol

Exact mass

≥98%

PSA

418.000 Å²

Logp

-1.600

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