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Product details

名称

NVS-PI3-4

分子类型

小分子

英文名称

NVS-PI3-4

货号

N649560-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NVS-PI3-4 is a specific PI3Kγ inhibitor. NVS-PI3-4 can be used for the research of allergies, inflammatory and cancer diseases In Vitro NVS-PI3-4 shows an exquisite cellular selectivity for PI3Kγ. NVS-PI3-4 reduces IgE/antigen-mediated phosphorylation of PKB/Akt in p110δ DA . NVS-PI3-4 (5 μM; 30 minutes; BMMCs) is not accumulate in specifically in mast cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:PI3Kγ

生化机理

NVS-PI3-4 是一种特异性 PI3Kγ 抑制剂。NVS-PI3-4 可用于过敏、炎症和癌症疾病的研究。

CAS号

941580-60-5

分子式

C20H26N4O3S

分子量

402.51 g/mol

PubChem编号

23585510

Isomeric SMILES

CC1=C(SC(=N1)NC(=O)NCCC(=O)NC(C)(C)C)C2=CC=C(C=C2)C(=O)C

IIUPAC Name

3-[[5-(4-acetylphenyl)-4-methyl-1,3-thiazol-2-yl]carbamoylamino]-N-tert-butylpropanamide

INCHI

1S/C20H26N4O3S/c1-12-17(15-8-6-14(7-9-15)13(2)25)28-19(22-12)23-18(27)21-11-10-16(26)24-20(3,4)5/h6-9H,10-11H2,1-5H3,(H,24,26)(H2,21,22,23,27)

InChi Key

IUPXLLWDLOWEBR-UHFFFAOYSA-N

Smiles

CC1=C(SC(=N1)NC(=O)NCCC(=O)NC(C)(C)C)C2=CC=C(C=C2)C(=O)C

PubChem CID

23585510

溶解性

DMSO : 250 mg/mL (621.10 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

402.173 Da

单同位素质量Monoisotopic Mass

402.173 Da

拓扑极表面积Topological Polar Surface Area

128.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

570

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.3

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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