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Product details

名称

NG-497

英文名称

NG-497

货号

N649972-5mg

包装规格

5mg

浓度

≥98%

储存温度

2-8°C储存,避光,干燥

运输条件

冰袋运输

产品介绍

NG-497 is a selective human adipose triglyceride lipase ( ATGL ) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. NG-497 has potential value for tumor research. In Vitro NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases and abolishes human adipocytes in a dose-dependent and reversible manner Lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

生化机理

NG-497 是一种选择性人脂肪甘油三酯脂酶（ATGL）抑制剂，其靶标是具有酶活性的人 ATGL 蛋白样结构域。NG-497 具有潜在的肿瘤研究价值。

CAS号

2598242-66-9

分子式

C18H21NO4

分子量

315.36 g/mol

Smiles

O=C(C1=CC(OC)=CC(C2=CC=C(OCC)C=C2)=N1)OC(C)C

溶解性

DMSO : 70 mg/mL (221.97 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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