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名称

NB-360

分子类型

小分子

英文名称

NB-360

货号

N651124-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor ( IC 50 : mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E Form:Solid IC50& Target:IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)

生化机理

NB-360 是一种强效、脑穿透性和口服生物可用性双重 BACE1/BACE2 抑制剂（IC 50：小鼠和人类 BACE1=5 nM；BACE2=6 nM）。NB-360 具有卓越的药理特性，能有效减少淀粉样蛋白-β 和神经炎症。

CAS号

1262857-73-7

分子式

C21H19F4N5O2

分子量

449.40 g/mol

PubChem编号

66665322

Isomeric SMILES

CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(CO[C@@](C(=N3)N)(C)C(F)(F)F)C)C#N

Smiles

CC1=CC(=CN=C1C(=O)NC2=CC(=C(C=C2)F)[C@@]3(CO[C@@](C(=N3)N)(C)C(F)(F)F)C)C#N

PubChem CID

66665322

溶解性

DMSO : 250 mg/mL (556.30 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

449.147 Da

单同位素质量Monoisotopic Mass

449.147 Da

拓扑极表面积Topological Polar Surface Area

113.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

812.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.200

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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