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名称

NLRP3/AIM2-IN-3

英文名称

NLRP3/AIM2-IN-3

货号

N651549-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis . NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC 50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization In Vitro NLRP3/AIM2-IN-3 (0-100 μM) displays remarkable inhibitory activity against NLRP3-and AIM2-but not NLRC4-dependent activation of caspase-1 and the release of IL-1b in human THP-1 macrophages. NLRP3/AIM2-IN-3 shows inhibition of IL-1b secretion by human THP-1 macrophages, with IC 50 of 0.098 μM, which is nearly 150-fold and 500-fold more potent than that of J774A.1 (14.62 μM) and bone marrow-derived macrophages (BMDMs) (48.98 μM), respectively. NLRP3/AIM2-IN-3 has almost no inhibitory effect on the AIM2 inflammasome-dependent activation of caspase-1 and release of IL-1b in J774A.1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:NLRP3

生化机理

NLRP3/AIM2-IN-3（化合物 59）是一种强效抑制剂，对 NLRP3 和 AIM2 炎症体依赖性的化脓作用具有不同的物种特异性。NLRP3/AIM2-IN-3 对受到 LPS 刺激的 THP-1 巨噬细胞的化脓过程具有抑制作用

CAS号

1787787-60-3

分子式

C16H14N2O2

分子量

266.29 g/mol

Smiles

O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3

溶解性

DMSO : 250 mg/mL (938.83 mM; Need ultrasonic) Methanol : 50 mg/mL (187.77 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

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