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Product details

名称

Niaprazine

分子类型

小分子

别名

尼普拉嗪

英文别名

英文名称

Niaprazine

货号

N651642-5mg

包装规格

5mg

浓度

≥99%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research. In Vitro Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (150-200 g)Dosage: 60 mg/kg Administration: Intraperitoneal injection; once Result: Increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Form:Solid

生化机理

尼普拉嗪是一种组胺 H1 受体拮抗剂。尼普拉嗪具有抗组胺和抗对羟色胺活性，可用于睡眠障碍研究。

CAS号

27367-90-4

分子式

C20H25FN4O

分子量

356.4 g/mol

EC号

248-431-5,620-536-4 | 248-431-5, 620-536-4

PubChem编号

71919

Isomeric SMILES

CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3

IIUPAC Name

N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide

INCHI

1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)

InChi Key

RSKQGBFMNPDPLR-UHFFFAOYSA-N

Smiles

CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NC(=O)C3=CN=CC=C3

PubChem CID

71919

关联CAS

119328-74-4,27367-90-4,119306-37-5,34426-53-4 (tri-hydrochloride)

MeSH Entry Terms

niaprazine;niaprazine trihydrochloride;Nopron

溶解性

DMSO : 100 mg/mL (280.55 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

356.201 Da

单同位素质量Monoisotopic Mass

356.201 Da

拓扑极表面积Topological Polar Surface Area

48.500 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

434.000

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.600

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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