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Product details

名称

NCX 470

英文名称

NCX 470

货号

N651745-5mg

包装规格

5mg

浓度

≥98%

储存温度

避光,-20°C储存,充氩

运输条件

超低温冰袋运输

产品介绍

NCX 470 is a second-generation nitric oxide (NO)-donating prostaglandin analogue. NCX 470 effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. NCX 470 can be used for the research of cular hypertension and glaucoma. In Vivo NCX 470 shows a better intraocular pressure-lowering efficacy than that of equimolar doses of bimatoprost in well-established animal models of glaucoma and ocular hypertension . NCX 470 (0.14% 30 μL; instillation; once) reduces IOP in transient ocular hypertensive rabbits. NCX 470 (0.042% 30 μL; instillation; once) is more effective than equimolar bimatoprost in cynomolgus monkeys with laser-induced ocular hypertension (OHT-monkeys), and normotensive dogs (ONT-dogs) at 18 hours post dosing. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: New Zealand white rabbits with 0.1 mL 5% sodium chloride solution injectionDosage: 0.14% Administration: Instillation; 0.14% 30 μL; once Result: Significantly blunted the IOP rise throughout the experimental period in transiently ocular hypertensive New Zealand white rabbits. Form:Oil

生化机理

NCX 470 是第二代一氧化氮（NO）捐赠前列腺素类似物。NCX 470 通过激活比马前列素介导的葡萄膜巩膜外流和一氧化氮介质，有效降低眼压和青光眼动物模型的眼压。

CAS号

1194396-71-8

分子式

C31H46N2O8

分子量

574.71 g/mol

PubChem编号

44462739

Isomeric SMILES

CCNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)OC(=O)CCCCCO[N+](=O)[O-])O)O

IIUPAC Name

[(E,3S)-1-[(1R,2R,3S,5R)-2-[(Z)-7-(ethylamino)-7-oxohept-2-enyl]-3,5-dihydroxycyclopentyl]-5-phenylpent-1-en-3-yl] 6-nitrooxyhexanoate

INCHI

1S/C31H46N2O8/c1-2-32-30(36)16-10-4-3-9-15-26-27(29(35)23-28(26)34)21-20-25(19-18-24-13-7-5-8-14-24)41-31(37)17-11-6-12-22-40-33(38)39/h3,5,7-9,13-14,20-21,25-29,34-35H,2,4,6,10-12,15-19,22-23H2,1H3,(H,32,36)/b9-3-,21-20+/t25-,26+,27+,28-,29+/m0/s1

InChi Key

NTQMJNDRYSYWNJ-BPXWCPHMSA-N

Smiles

CCNC(=O)CCCC=CCC1C(CC(C1C=CC(CCC2=CC=CC=C2)OC(=O)CCCCCO[N+](=O)[O-])O)O

PubChem CID

44462739

溶解性

DMSO : 100 mg/mL (174.00 mM; Need ultrasonic)

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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