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Product details

名称

NBI-98782

英文名称

NBI-98782

货号

N654677-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM Target: VMAT2The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection.

生化机理

NBI-98782(alpha-dihydrotetrabenazine) 是一种囊泡单胺转运体（VMAT2）抑制剂，Ki 值为 0.97 nM：(+)-异构体在体外显示出对 VMAT2 的高亲和力（Ki = 0.97 +/- 0.48 nM）。

CAS号

85081-18-1(DMSO)

分子式

C19H29NO3

分子量

319.44 g/mol

Smiles

COC(C=C1CCN2C[C@@H](CC(C)C)[C@@H]3O)=C(C=C1[C@]2(C3)[H])OC

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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