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名称

N-Acetyl lysyltyrosylcysteine amide

别名

N-乙酰赖氨酰酪氨酰半胱氨酸酰胺

英文名称

N-Acetyl lysyltyrosylcysteine amide

货号

N654738-1ml

包装规格

1ml

浓度

10mM in Water

储存温度

避光,-80℃储存

运输条件

超低温冰袋运输

产品介绍

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation. In Vivo N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice . N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice . N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode) Dosage: 10 mg/kg Administration: I.p.; daily for 3-7 days Result: Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.

生化机理

N-Acetyl lysyltyrosylcysteine amide 是一种强效、可逆、特异和无毒的髓过氧化物酶（MPO）三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 能有效抑制 MPO 在体内生成有毒氧化剂。N-乙酰基赖氨酰酪酰半胱氨酸酰胺能有效抑制 MPO 在体内生成毒性氧化剂。

CAS号

1287585-40-3(Water)

分子式

C20H31N5O5S

分子量

453.56 g/mol

Smiles

SC[C@@H](C(N)=O)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CCCCN)NC(C)=O)=O)=O

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

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