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Product details

名称

NMDAR/TRPM4-IN-2 free base

别名

NMDAR/TRPM4-IN-2 游离碱

英文名称

NMDAR/TRPM4-IN-2 free base

货号

N654961-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC 50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss. In Vitro NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner. NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

生化机理

NMDAR/TRPM4-IN-2 游离碱（化合物 8）是一种强效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 游离碱具有神经保护活性。NMDAR/TRPM4-IN-2 游离碱可防止 NMDA 诱导的海马细胞死亡和线粒体功能障碍。

CAS号

1353979-43-7(DMSO)

分子式

C11H17BrN2

分子量

257.175 g/mol

Smiles

CCN(CCN)CC1=CC(=CC=C1)Br

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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