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名称

NH-3

英文名称

NH-3

货号

N655269-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment In Vivo NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose. MCE has not independently confirmed the accuracy of these methods. They are for reference only. IC50& Target:IC50: 55 nM (THR)

生化机理

NH-3 是一种口服活性、可逆的甲状腺激素受体（THR）拮抗剂，其 IC 50 为 55 nM。NH-3 是选择性甲状腺激素受体 GC-1 的衍生物，可抑制甲状腺激素与其受体的结合，并抑制辅助因子的招募[1]。

CAS号

447415-26-1(DMSO)

分子式

C28H27NO6

分子量

473.52 g/mol

Smiles

O=C(O)COC1=CC(C)=C(CC2=CC(C#CC3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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