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Product details

名称

NCGC00029283

英文名称

NCGC00029283

货号

N655448-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC 50 s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively. In Vitro NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: U2-OS cells Concentration: 1 μM, 10 μM, 100 μM Incubation Time: 24 h, 48 h, 72 h Result: Showed a reduction in U2-OS cell proliferation.

生化机理

NCGC00029283 是一种维尔纳综合征螺旋酶核酸酶（WRN）螺旋酶抑制剂，对 WRN、BLM 和 FANCJ 螺旋酶的 IC 50 s 分别为 2.3 μM、12.5 μM 和 3.4 μM。

CAS号

714240-31-0(DMSO)

分子式

C18H12FN3O3

分子量

337.30 g/mol

Smiles

COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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