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Product details

名称

NB-360

英文名称

NB-360

货号

N656540-1ml

包装规格

1ml

浓度

10mM in DMSO

储存温度

-80℃储存

运输条件

超低温冰袋运输

产品介绍

NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor ( IC 50 : mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E IC50& Target:IC50: 5 nM (Mouse and human BACE1), 6 nM (BACE2)

生化机理

NB-360 是一种强效、脑穿透性和口服生物可用性双重 BACE1/BACE2 抑制剂（IC 50：小鼠和人类 BACE1=5 nM；BACE2=6 nM）。NB-360 具有卓越的药理特性，能有效减少淀粉样蛋白-β 和神经炎症。

CAS号

1262857-73-7(DMSO)

分子式

C21H19F4N5O2

分子量

449.40 g/mol

Smiles

O=C(C1=NC=C(C#N)C=C1C)NC2=CC=C(F)C([C@]3(C)CO[C@](C(F)(F)F)(C)C(N)=N3)=C2

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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