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Product introduction

Nrf2 activator-2 (compound O15) 是一种蛇床子素衍生物，一种有效的 Nrf2 激动剂，在 293 T 细胞中的 EC50 为 2.9 μM。Nrf2 activator-2有效抑制 Keap1 和 Nrf2 的相互作用，从而显示出对 Nrf2 的激活作用。Nrf2 activator-2 显示细胞中泛素化 Nrf2 水平显着降低。 Nrf2 activator-2 (compound O15), a Osthole derivative, is a potent Nrf2 agonist with an EC50 of 2.9 μM in 293 T cells. Nrf2 activator-2 effectively inhibits the interaction between Keap1 and Nrf2, thus showing the activation effect on Nrf2. Nrf2 activator-2 shows a marked decrease in the level of ubiquitinated Nrf2 in cells

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Chinese name

Nrf2 activator-2

English name

Nrf2 activator-2

Chinese alias

Nrf2激活剂-2

English alias

6-Bromo-8,8-dimethyl-3-phenyl-9,10-dihydropyrano[2,3-f]chromen-2(8H)-one

CAS number

2770448-53-6

molecular formula

C20H17BrO3

molecular weight

385.25 g/mol

Exact mass

≥95%

PSA

Logp

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