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Product details

名称

Numidargistat dihydrochloride

别名

努米达司他二盐酸盐

英文名称

Numidargistat dihydrochloride

货号

N661606-1ml

包装规格

1ml

浓度

10mM

储存温度

充氩,干燥,-80℃储存

运输条件

超低温冰袋运输

产品介绍

Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent. IC50& Target:IC50: 86 nM (Arginase 1), 296 nM (Arginase 2) In Vitro:Numidargistat dihydrochloride is a potent and orally-bioavailable inhibitor of arginase, with IC 50 s of 86 and 296 nM for recombinant human arginase 1 and 2, respectively. Numidargistat dihydrochloride inhibits native rginase 1 (Arg1) in human granulocyt In Vivo:Numidargistat dihydrochloride (100mg/kg, p.o., twice per day) increases the number of tumor-infiltrating cytotoxic cells and decreases myeloid cells in mice. Numidargistat dihydrochloride in combination with PD-L1 blockade or LY 188011 inhibits tumor gro Biological Activity:Numidargistat (CB-1158) dihydrochloride is a potent and orally active inhibitor of arginase , with IC 50 s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2 , respectively. Immuno-oncology agent.

分子式

C11H24BCl2N3O5

分子量

360.04 g/mol

Smiles

O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1.Cl.Cl

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

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「No related articles yet」

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