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Product introduction
RMC-7977 是一种具有口服活性的三复合 RAS 抑制剂,可同时结合亲环蛋白 A (CYPA) (Kd = 195 nM) 和 KRAS (G12V) (Kd = 292 μM),对 KRAS、NRAS 和 HRAS 三种 RAS 蛋白及其各种野生型和突变型变体具有广谱抑制活性。RMC-7977 通过抑制 ERK、CRAF和 RSK 磷酸化以及增加 PARP 剪切来诱导细胞凋亡 (Apoptosis),可导致肿瘤消退,减少 KRASG12C 癌症模型的耐药性,并且在多种 RAS 癌症模型中具有良好的耐受性。
Chinese name
RMC-7977
English name
RMC-7977
Chinese alias
-
English alias
-
CAS number
2765082-12-8
molecular formula
C47H60N8O6S
molecular weight
865.11 g/mol
Exact mass
≥99%
PSA
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RMC-7977 98% 1mg

Macklin RMC-7977 98% 1mg, CAS 2765082-12-8, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:N726637-1mg
Product model:1mg
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Lead Time:30days
sold 461 Items
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