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Product introduction
诺米芬辛是一种N-甲基化的四氢异喹啉,在C-4和C-8位分别带有苯基和氨基取代基。它具有多巴胺摄取抑制剂的作用。
Chinese name
诺米芬辛 马来酸盐
English name
2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
Chinese alias
诺米芬新马来酸盐
English alias
( inverted exclamation markA)-Nomifensine maleat | SR-01000000201-2 | D05200 | DTXCID9025790 | HMS502H11 | 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (2Z)-2-butenedioate (1:1) | Tox21_111258_1 | 1,2,3,4-Tetrahydro-2-methyl-4-phenylisoquino
CAS number
32795-47-4
molecular formula
C16H18N2
molecular weight
238.33
Exact mass
≥98%
PSA
29.3
Logp
2.6
Safety
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • interaction: 六名癫痫患者(年龄21-28岁)服用苯妥英和苯巴比妥(苯巴比妥)或苯妥英和卡马西平,以及6名对照者(年龄21-25岁),分别给予单次口服剂量30 mg米安色林和100 mg诺米芬辛,间隔至少一个月,以确定抗惊厥药治疗是否会影响米安色林和诺米芬辛的药代动力学。结果显示,接受抗惊厥药治疗的癫痫患者血浆中米安色林和诺米芬辛的水平显著降低。
  • non-human toxicity value: LD50 豚鼠静脉注射 264 mg/kg
  • Hazard categories and classifications: 特定靶器官毒性-单次接触 3 (100%)
  • Non-human toxic extract: /实验室动物:急性暴露/ 在 conscious rabbits 中评估了马普替林、米安色林和诺米芬辛之间的相对急性心血管毒性,在腹腔注射50 mg/kg后150分钟内。6只接受米安色林的兔子没有死亡,但8只接受马普替林的兔子中有3只死亡,8只接受诺米芬辛的兔子中有1只死亡。心输出值仅在米安色林组降低,而肾血流量分别降低了35.8%、46.8%和28%(马普替林、米安色林和诺米芬辛)。左心室压和平均动脉压在马普替林和米安色林组显著下降。所有兔子都表现出心室和心室上性早搏,但QRS增宽和右束支传导阻滞仅在马普替林中观察到...
  • Antidote and first aid: /SRP:/ 高级治疗:对于意识不清、严重肺水肿或严重呼吸窘迫的患者,考虑经口或经鼻气管插管进行气道控制。使用气囊面罩装置进行正压通气技术可能有益。考虑对肺水肿进行药物治疗...。对于严重支气管痉挛,考虑给予β激动剂如沙丁胺醇...。监测心律并根据需要治疗心律失常...。开始静脉注射D5W /SRP: "保持通畅",最小流速/。如果出现低血容量迹象,使用0.9%生理盐水(NS)或乳酸盐林格氏液。对于伴有低血容量体征的低血压,谨慎给予液体。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用...
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
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Nomifensine maleate 10mM in DMSO 1ml

Nomifensine maleate 10mM in DMSO 1ml Macklin 32795-47-4, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number:N766829-1ml
Product model:1ml
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