- exposure pathway： 肠溶胶囊是肠溶包衣的（因为奥美拉唑对酸不稳定），所以颗粒离开胃后奥美拉唑的吸收开始。吸收迅速。血浆峰浓度在0.5-3.5小时内出现。肠溶胶囊的绝对生物利用度（与静脉给药相比）在20-40毫克剂量下为30-40%，这是由于系统前代谢所致。重复给药时此值略有增加。基于相对生物利用度研究，PRILOSEC（奥美拉唑镁）肠溶口服混悬剂的AUC和Cmax分别为PRILOSEC肠溶胶囊的87%和88%。有趣的是，当40毫克肠溶胶囊与或不与苹果酱一起服用时，生物等效。然而，当20毫克...
- Toxicity summary： 奥美拉唑是一种质子泵抑制剂，通过特异性抑制胃壁细胞的H<sup>+</sup>/K<sup>+</sup>-ATP酶来抑制胃酸分泌。通过特异性作用于质子泵，奥美拉唑阻断酸产生的最后一步，从而降低胃酸度。
- Health Effects： 可能包括骨重建干扰和维生素B12减少。[维基百科]
- Symptoms and Signs： 过量症状包括意识模糊、嗜睡、视力模糊、心动过速、恶心、出汗、潮红、头痛和口干。
- Hazard categories and classifications： 急性毒性 4（100%）
- Carcinogen Classification： 对人类无致癌性迹象（未被IARC列出）。
- Effects During Pregnancy and Lactation： 一名26岁的不丹女性肾移植患者接受他克莫司2mg每日两次、泼尼松龙5mg每日一次、来氟米特20mg每日一次、硝苯地平40mg每日两次和肼屈嗪50mg每日三次维持治疗。她因腹痛到急诊室就诊。调整了他克莫司剂量，并开始口服奥美拉唑。3天后，她出现左侧乳房泌乳。据患者称，7年前她接受肾移植时曾经历过同样的反应。停用奥美拉唑后，3天后泌乳停止。作者将这种泌乳评定为 definitely 由奥美拉唑引起。
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Research chemical 1ml
Research chemical 1ml; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1ml.
