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Product introduction

Osimtinib (AZD9291) 是一种共价结合、不可逆和突变选择性的 EGFR 抑制剂，其有效抑制 L858R (IC50=12 nM) 和 L858R/T790M (IC50=1 nM) EGFR。Osimtinib 解决了肺癌 T790M 突变介导的 EGFR 抑制剂耐药。 Osimertinib (AZD9291) is a irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.

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Chinese name

奥希替尼 (AZD9291), 表皮生长因子受体 erbB1 抑制剂

English name

Osimertinib (AZD9291)

Chinese alias

N-[2-[[2-(二甲基氨基)乙基]甲基氨基]-4-甲氧基-5-[[4-(1-甲基-1H-吲哚-3-基)-2-嘧啶基]氨基]苯基]-2-丙烯酰胺

English alias

Mereletinib | AZD-9291

CAS number

1421373-65-0

molecular formula

C28H33N7O2

molecular weight

499.62 g/mol

Exact mass

PSA

87.600 Å²

Logp

3.7

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