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Product details

名称

ORM-15341

分子类型

未知

英文别名

GMBPVBVTPBWIKC-NSHDSACASA-N | 9EPS75QMTL | 1297537-33-7 | HY-19337 | XBC53733 | NCGC00485475-01 | A920206 | Q27272459 | AC-36362 | MS-26697 | ZB1629 | EX-A3189 | AKOS030526386 | 3-acetyl-N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-1H-py

英文名称

ORM-15341

货号

O646660-5mg

包装规格

5mg

浓度

≥98%

储存温度

-20°C储存

运输条件

超低温冰袋运输

产品介绍

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.IC50 value: 38 nMTarget: androgen receptor in vitro: In competitive AR binding assays, the inhibition constant (Ki) values of ORM-15341 was 8 nM. ORM-15341 functions as a full antagonist for all tested mutant ARs , with IC50 of 25, 51, 700, and 1160 nM for wtAR, AR(F876L), AR(T877A), and AR(W741L). Form:Solid

生化机理

在稳定表达全长 hAR 和雄激素反应型荧光素酶报告基因构建体的 AR-HEK293 细胞中进行的转录激活试验表明，ORM-15341 是一种强效的人 AR（hAR）完全拮抗剂，其 IC50 值为 38 nM：38 n

CAS号

1297537-33-7

分子式

C19H17ClN6O2

分子量

396.83 g/mol

EC号

941-760-1

PubChem编号

52919826

Isomeric SMILES

C[C@@H](CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=CC(=NN3)C(=O)C

IIUPAC Name

3-acetyl-N-[(2S)-1-[3-(3-chloro-4-cyanophenyl)pyrazol-1-yl]propan-2-yl]-1H-pyrazole-5-carboxamide

INCHI

1S/C19H17ClN6O2/c1-11(22-19(28)18-8-17(12(2)27)23-24-18)10-26-6-5-16(25-26)13-3-4-14(9-21)15(20)7-13/h3-8,11H,10H2,1-2H3,(H,22,28)(H,23,24)/t11-/m0/s1

InChi Key

GMBPVBVTPBWIKC-NSHDSACASA-N

Smiles

CC(CN1C=CC(=N1)C2=CC(=C(C=C2)C#N)Cl)NC(=O)C3=CC(=NN3)C(=O)C

PubChem CID

52919826

关联CAS

1297537-33-7

溶解性

DMSO : 100 mg/mL (252.00 mM; Need ultrasonic)

氢键供体数Hydrogen Bond Donor Count

氢键受体数Hydrogen Bond Acceptor Count

可旋转键计数Rotatable Bond Count

精确质量Exact Mass

396.11 Da

单同位素质量Monoisotopic Mass

396.11 Da

拓扑极表面积Topological Polar Surface Area

116.000 Å²

重原子数Heavy Atom Count

形式电荷Formal Charge

复杂度Complexity

637

同位素原子数Isotope Atom Count

共价键合单元计数Covalently-Bonded Unit Count

XLogP3

2.2

Safety

「No Dangerous Attributes」

「No upstream and downstream information yet」

Technical Documents

「No technical documents」

Articles

「No related articles yet」

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